Comic book store owner Stuart Bloom is tasked with restoring reality after he breaks a device built by Sheldon and Leonard, accidentally bringing about a multiverse Armageddon. Stuart is aided in this quest by his girlfriend Denise, geologist friend Bert, and quantum physicist/all-around pain in the ass Barry Kripke.
Stuart, Bert, Denise, and Barry Kripke find themselves in what appears to be an ideal and peaceful Earth – that happens to be controlled by a repressive and vicious AI.
Suddenly back in the comic book store, the gang must make sense of where they are in the universe...and where is that laughter coming from? Meanwhile, Stuart forgets an important date.